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Updated: Oct 1, 2025
08:55
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
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Positron Emission Tomography/Computed Tomography in Thyroid Cancer.
Chandrasekhar Bal1, Dhritiman Chakraborty2, Dikhra Khan1
1Department of Nuclear Medicine, AIIMS, New Delhi 110029, India.
PET Clinics
|March 8, 2022
Summary
Fluorine-18-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG PET/CT) is crucial for managing thyroid cancer, aiding in nodule evaluation and detecting recurrent or metastatic disease. Emerging theranostic agents and 124I PET/CT show promise for advanced thyroid malignancy management.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiology
Background:
- 18F-FDG PET/CT is a key imaging modality in thyroid cancer management.
- Its utility extends to evaluating incidentally discovered suspicious nodules and staging known malignancies.
Purpose of the Study:
- To review the established and emerging roles of PET/CT in thyroid cancer.
- To highlight the diagnostic and theranostic applications of various radiotracers.
Main Methods:
- Review of current literature on 18F-FDG PET/CT in thyroid malignancies.
- Discussion of novel PET/CT tracers (68Ga-SSA, 68Ga-PSMA, 68Ga-FAPI, 68Ga-DOTA-RGD) and 124I PET/CT.
Main Results:
- 18F-FDG PET/CT is effective for assessing incidentally found nodules and recurrent/metastatic disease, especially in the TENIS scenario.
- Theranostic tracers show potential for targeted therapy and personalized treatment strategies.
- 124I PET/CT is under investigation for improved resolution and dosimetry.
Conclusions:
- 18F-FDG PET/CT remains indispensable for thyroid cancer management, from initial workup to recurrence detection.
- Theranostic PET/CT agents and 124I PET/CT represent exciting advancements for future thyroid cancer treatment and monitoring.
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