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Updated: Oct 1, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
[Sinonasal cancers]
François-Régis Ferrand1, Juliette Thariat2, Benjamin Verillaud3
1Institut de recherche biomédicale des armées, Brétigny-sur-Orge, France, département de carcinologie cervicofaciale, institut Gustave-Roussy, Villejuif, France.
Sinonasal cancers (SNC) are rare head and neck tumors. Increased physician awareness of SNC diagnosis, treatment, and functional outcomes is crucial for optimal patient care and monitoring.
Area of Science:
- Oncology
- Head and Neck Surgery
- Rare Tumors
Background:
- Sinonasal cancers (SNC) are rare tumors within the head and neck cancer spectrum.
- SNC encompass diverse histological subtypes, complicating diagnosis and management.
- Physicians require enhanced awareness of diagnostic and therapeutic strategies for SNC.
Purpose of the Study:
- To increase physician awareness of sinonasal cancer diagnosis and treatment.
- To highlight functional consequences and long-term monitoring of SNC patients.
- To review current and emerging therapeutic options for SNC.
Main Methods:
- Review of histological entities within SNC.
- Discussion of advanced therapeutic modalities including endoscopic surgery, radiotherapy, and systemic treatments.
- Emphasis on the role of expert networks (REFCOR) and patient support associations (CORASSO).
Main Results:
- SNC require specialized diagnostic and therapeutic approaches due to their rarity and heterogeneity.
- New treatments like endoscopic surgery and advanced radiotherapy offer improved outcomes.
- Multidisciplinary collaboration through networks and associations is vital for comprehensive patient management.
Conclusions:
- Optimal management of sinonasal cancers necessitates heightened physician awareness and specialized care.
- Integration of novel surgical, radiological, and systemic therapies improves patient outcomes.
- Expert networks and patient support systems are essential for holistic SNC care.
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