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Related Experiment Video

Updated: Oct 1, 2025

Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
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Improving neurodevelopment in Zika-exposed children: A randomized controlled trial.

Randall Waechter1,2,3, Kemi S Burgen2,3, Bianca Punch2

  • 1Department of Neuroscience, Physiology, and Behavioral Sciences; School of Medicine; St George's University; Grenada, West Indies.

Plos Neglected Tropical Diseases
|March 8, 2022
PubMed
Summary
This summary is machine-generated.

A 12-week Responsive Caregiving Intervention significantly improved language and positive behavior in young children exposed to the Zika virus (ZIKV). This evidence-based program offers crucial support for neurodevelopmental outcomes in Zika-exposed children (ZEC).

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Area of Science:

  • Neurodevelopmental disorders
  • Public Health
  • Pediatrics

Background:

  • Prenatal Zika virus (ZIKV) exposure can cause microcephaly and subtle malformations of cortical development (MCD).
  • Zika-exposed children (ZEC) may experience delays in language, cognition, motor skills, and visual acuity.
  • Early interventions in the first 1,000 days are critical for improving developmental trajectories.

Purpose of the Study:

  • To evaluate the impact of a 12-week Responsive Caregiving Intervention on neurodevelopmental outcomes.
  • To assess the intervention's effectiveness in Zika-exposed children aged 24-30 months.
  • To provide an evidence-based intervention for mothers of ZEC.

Main Methods:

  • A randomized controlled trial was conducted in Grenada using an existing ZIKV cohort.
  • Children were assessed at 24 months, then randomized to Intervention or Waitlist Control groups for a 12-week program (ages 24-30 months).
  • Neurodevelopmental measures were re-assessed post-intervention. A GEE model analyzed language and behavior scores.

Main Results:

  • The final sample included 13 children in the Intervention group and 26 in the Control group.
  • Children in the Intervention group showed significantly higher language (p=0.021) and positive behavior (p=0.005) scores.
  • The intervention demonstrated a medium effect on language (d=0.66) and a large effect on positive behavior (d=0.83).

Conclusions:

  • A 12-week Responsive Caregiving Intervention significantly enhances language and positive behavior in 30-month-old normocephalic children with in utero ZIKV exposure.
  • This program offers a valuable, evidence-based neurodevelopmental support option for mothers of ZEC.
  • The findings highlight the importance of early, targeted interventions for children affected by ZIKV.