Related Experiment Video
Updated: Oct 1, 2025
07:28
Microscopic Replantation of Penile Glans Amputation Due to Circumcision
Published on: June 3, 2022
20.4K
[Leukemia Relapse as Granulocytic Sarcoma Beginning with Penile Localization : A Case Report]
Shogo Aizawa1, Takahiro Osawa1, Hiroshi Kikuchi1
1The Department of Renal and Genitourinary Surgery, Graduate School of Medicine, Hokkaido University.
Hinyokika Kiyo. Acta Urologica Japonica
|March 9, 2022
Summary
A painful penile mass in a leukemia patient was diagnosed as granulocytic sarcoma. This highlights that extramedullary recurrence can occur even when bone marrow tests suggest remission.
Area of Science:
- Hematology
- Oncology
- Urology
Background:
- Acute myeloid leukemia (AML) survivors undergoing allogeneic hematopoietic stem cell transplantation (HSCT) face risks of relapse.
- Extramedullary disease recurrence can manifest in various organs, posing diagnostic challenges.
Observation:
- A 57-year-old man presented with a painful penile mass.
- Initial bone marrow biopsy after HSCT did not reveal leukemia recurrence.
- The penile tumor enlarged, and peripheral blood showed blasts, raising suspicion for relapse.
Findings:
- Biopsy confirmed the penile tumor as granulocytic sarcoma, a rare extramedullary manifestation of leukemia.
- The case demonstrated leukemia recurrence in an extramedullary site despite initial negative bone marrow findings.
Implications:
- This case underscores the importance of considering extramedullary recurrence in leukemia survivors, even with seemingly negative bone marrow results.
- Physicians should maintain a high index of suspicion for granulocytic sarcoma in leukemia patients with unexplained masses.
- Early recognition and diagnosis of extramedullary disease are crucial for timely and effective treatment adjustments.
