Molybdenum disulfide (MoS₂)-based nanostructures for tissue engineering applications: prospects and challenges

Area of Science:

• Materials Science
• Biotechnology
• Nanotechnology

Background:

• Molybdenum disulfide (MoS₂) nanostructures possess unique physicochemical, optical, and electrical properties.
• While industrial applications are known, biological uses of MoS₂ are less explored.
• Nanotechnology integration advances tissue regeneration and engineering.

Purpose of the Study:

• To review MoS₂ nanostructures' structural properties.
• To investigate MoS₂ interactions with biological systems, including toxicity, biocompatibility, and cellular responses.
• To discuss MoS₂-based scaffolds for tissue engineering and large organ regeneration.

Main Methods:

• Literature review of MoS₂ nanostructures.
• Analysis of studies on MoS₂'s biological interactions (cytotoxicity, biocompatibility, cell proliferation, adhesion, immunomodulation).
• Evaluation of MoS₂-based scaffolds in tissue engineering applications.

Main Results:

• MoS₂ nanostructures exhibit diverse structural characteristics.
• MoS₂ demonstrates varying cellular toxicity and biocompatibility profiles.
• MoS₂ influences cell proliferation, adhesion, and immunomodulation.
• MoS₂-based scaffolds show utility in tissue engineering.

Conclusions:

• MoS₂ nanostructures are promising for tissue engineering applications.
• Further research is needed to overcome challenges for widespread use in tissue and organ regeneration.
• MoS₂ holds potential for advanced tissue engineering solutions.