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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
Published on: March 4, 2017
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pH-Responsive Nanocarriers in Cancer Therapy.
Nour M AlSawaftah1,2, Nahid S Awad1, William G Pitt3
1Department of Chemical Engineering, College of Engineering, American University of Sharjah, Sharjah P.O. Box. 26666, United Arab Emirates.
Polymers
|March 10, 2022
Summary
pH-sensitive nanoparticles offer a promising approach to cancer therapy by enabling targeted drug delivery and controlled release. This review surveys strategies for developing these advanced nanoparticles for improved tumor treatment.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Oncology
Background:
- Conventional chemotherapy faces limitations in drug delivery and efficacy.
- Stimuli-responsive nanoparticles offer enhanced drug delivery and controlled release at tumor sites.
- Tumor microenvironments, particularly intracellular pH, can be exploited for targeted drug release.
Purpose of the Study:
- To review strategies for developing pH-sensitive nanoparticles for cancer therapy.
- To highlight the advantages of pH-sensitive nanoparticles over conventional delivery systems.
- To explore the potential of exploiting tumor-specific pH for enhanced drug delivery.
Main Methods:
- Survey of existing literature on pH-sensitive nanoparticle development.
- Analysis of different stimuli-responsive mechanisms, focusing on pH.
- Evaluation of strategies for designing nanoparticles sensitive to tumor acidity.
Main Results:
- pH-sensitive nanoparticles demonstrate high efficiency in delivering drugs to tumors.
- The acidic intracellular pH of solid tumors is a key target for these nanoparticles.
- Various strategies exist for engineering nanoparticles that respond to pH changes.
Conclusions:
- pH-sensitive nanoparticles represent a significant advancement in targeted cancer therapy.
- Exploiting the tumor's acidic microenvironment is a viable strategy for drug delivery.
- Further development of pH-sensitive nanoparticles holds great promise for improving cancer treatment outcomes.
