Related Experiment Video
Updated: Sep 30, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Double Addition Reactions Involving Vinyl-Substituted N-Heterocycles and Active Methylene Compounds
Jacob C Hood1, Yannick Tshikaya1, Aaren R Manz1
1Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, United States.
Abstract:
A series of conjugate addition reactions have been performed with vinyl-substituted N-heterocycles in acid-catalyzed conversions. Using active methylene compounds, double conjugate addition reactions have been accomplished to provide dipyridyl and related heterocyclic products. These conversions have utilized 1,3-dicarbonyl compounds, cyano esters, a cyano sulfone, and malonyl nitrile as nucleophiles. The Michael accepting groups include vinyl-substituted pyridines, quinoline, and pyrazine. Double conjugate addition reactions have also been accomplished with 2,6-divinylpyridine and related systems.
More Related Videos
07:50Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
11:44Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Related Concept Videos
Conjugate Addition of Enolates: Michael Addition
Cycloaddition Reactions: Overview
Conjugate Addition to α,β-Unsaturated Carbonyl Compounds
Nucleophilic Aromatic Substitution: Elimination–Addition
Electrophilic Addition to Alkynes: Hydrohalogenation
Cycloaddition Reactions: MO Requirements for Thermal Activation