Related Experiment Video
Updated: Sep 30, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
The Early Predictive Value of Circulating Monocytes and Eosinophils in Coronary DES Restenosis
Shumei Li1, Hong Qiu2, Zhaorong Lin1
1Department of Cardiology, Fujian Institute of Coronary Heart Disease, Fujian Medical University Union Hospital, Fuzhou, China.
Insights
Elevated monocytes and eosinophils predict in-stent restenosis (ISR) after drug-eluting stent implantation. Monocyte levels at three months and baseline eosinophils are key early indicators of ISR risk.
Area of Science:
- Cardiology
- Hematology
- Biomedical Science
Background:
- Monocytes and eosinophils contribute to intracoronary inflammation, increasing risks of plaque instability and in-stent restenosis (ISR).
- Understanding the role of these cells is crucial for managing patients post-stenting.
Purpose of the Study:
- To determine if circulating monocytes and eosinophils can predict early in-stent restenosis (ISR) in patients undergoing stenting.
- To establish potential biomarkers for ISR risk stratification.
Main Methods:
- Retrospective analysis of 4,392 patients who received successful drug-eluting stents (DES).
- Comparison of hematological measurements between 140 patients with ISR and 141 patients without ISR.
- Long-term follow-up with scheduled assessments and angiographic review.
Main Results:
- Significant association found between monocyte count/percentage and ISR (P < 0.001), detectable from 3 months postoperatively.
- Eosinophil count/percentage also linked to ISR (P = 0.001-0.003), with baseline eosinophils showing the strongest association.
- ROC analysis identified predictive cutoff points for monocyte and eosinophil levels.
Conclusions:
- Elevated monocytes at 3 months post-DES implantation and baseline eosinophils are strong early predictors of ISR.
- Persistent monocyte elevation may signal ongoing ISR risk after percutaneous coronary intervention (PCI).
- These findings offer valuable insights for early ISR detection and patient management.
Background:
Monocytes and eosinophils are involved in intracoronary inflammatory responses, aggravating coronary artery plaque instability and in-stent restenosis (ISR).
Aims:
To investigate an early prediction of ISR in patients undergoing stenting by circulating monocytes and eosinophils.
Methods:
The single-center data of patients undergoing successful drug-eluting stents (DES) implantation from January 1, 2017 to April 30, 2020 were retrospectively analyzed. Of the 4,392 patients assessed, 140 patients with restenosis and 141 patients without restenosis were enrolled. A scheduled postoperative follow-up was proceeded in four sessions: 0-3 months, 3-6 months, 6-12 months, and >12 months. The hematological and biochemical measurement was collected. The angiographic review was completed within two postoperative years.
Results:
Significant associations of monocyte count and percentage with ISR were evident [odds ratio (OR): 1.44, 95% CI: 1.23-1.68, P < 0.001; OR: 1.47, 95%CI: 1.24-1.74, P < 0.001, respectively], which began at 3 months postoperatively and persisted throughout the follow-up period. Eosinophil count and percentage were associated with ISR (OR: 1.22, 95%CI: 1.09-1.36, P = 0.001; OR: 1.23, 95%CI: 1.07-1.40, P = 0.003, respectively), with ISR most significantly associated with the baseline eosinophils. The receiver operating characteristic (ROC) curve analysis showed that the cutoff points of monocyte count and percentage in the ISR prediction were 0.46× 109/L and 7.4%, respectively, and those of eosinophil count and percentage were 0.20 × 109/L and 2.5%, respectively.
Conclusion:
This study, with a long-term follow-up, first provides evidence that the elevated monocytes at three postoperative months and baseline eosinophils may be strong early predictors of ISR after drug-eluting stent implantation. Persistent elevation of monocytes may also be a signal of ISR after percutaneous coronary intervention (PCI).
More Related Videos
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
09:41Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions
Published on: October 17, 2017