Electrochemical aptasensing strategy based on a multivariate polymertitanium-metal-organic framework for zearalenone...

An electrochemical aptasensing strategy was developed with a novel bioplatform based on a multivariate titanium metal-organic framework, i.e. MTV polyMOF(Ti), to detect zearalenone (ZEN). MTV polyMOF(Ti) was prepared by using mixed linkers of polyether polymer (pbdc-xa or L₈, pbdc = poly(1,4-benzenedicarboxylate) and 1,4-benzenedicarboxylic acid (H₂bdc or L₀) as well as tetrabutyl titanate as nodes (MTV polyMOF(Ti)-L_8,0). Compared with Ti-MOFs synthesized by using the single ligand of L₈ or L₀, MTV polyMOF(Ti)-L_8,0 shows more porous structure assembled with multilayered nanosheets. In light of the improved electrochemical activity and strong bioaffinity to the aptamer, the aptasensor based on MTV polyMOF(Ti)-L_8,0 shows excellent performance for detecting ZEN with the ultralow detection limit at fg mL^-1 level in the linear range of 10 fg mL^-1 to 10 ng mL^-1, along with good selectivity, reproducibility, stability, regenerability, and applicability.