Challenging Aspects to Precise Health Strategies in Native Hawaiian and Other Pacific Islanders Using Statins.

Area of Science:

• Public Health
• Cardiology
• Genetics

Background:

• Cardiometabolic disorders (CD) like cardiovascular disease (CVD), diabetes, and obesity are leading health concerns in the U.S.
• Native Hawaiian and Other Pacific Islanders (NHOPI) disproportionately experience higher rates of CD and dyslipidemia, a key CVD risk factor.

Purpose of the Study:

• To explore challenges in public health strategies for NHOPI individuals taking statins.
• To identify modifiable determinants to prevent or reduce statin side effects in NHOPI.
• To propose culturally informed additional therapies for NHOPI.

Main Methods:

• Mini-review of existing literature on statin therapy and side effects in NHOPI.
• Analysis of sociodemographic, behavioral, and biological factors influencing statin response.
• Exploration of culturally tailored interventions.

Main Results:

• NHOPI populations exhibit a higher prevalence of dyslipidemia and potential for statin-related side effects.
• Sociodemographic, behavioral, and biological factors may influence statin efficacy and tolerability across ethnic groups.
• Evidence-based, culturally sensitive approaches are crucial for effective treatment.

Conclusions:

• Targeted public health strategies are necessary to address health disparities in NHOPI related to cardiometabolic disorders.
• Further research into culturally informed therapies can optimize statin use and minimize side effects in NHOPI.
• Personalized medicine approaches considering ethnic-specific factors are essential for NHOPI patients.