Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Remote Modification-Induced Butterfly Effect on Nonfullerene Acceptor Aggregation for Efficient Organic Solar Cells.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Structured illumination for surface-resolved grazing-incidence X-ray scattering.

Journal of synchrotron radiation·2026
Same author

Synergistic Control of Radiative Decay and Exciton Splitting Dynamics for Efficient Organic Solar Cells Processed by Non-Halogenated Solvent.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Thulium fiber laser versus holmium:YAG laser for ureteroscopic lithotripsy: a single-center retrospective cohort study.

Frontiers in surgery·2026
Same author

Formation of Bimetallic Nanoparticles via Exsolution Using a Reducible Metal Oxide Capping Layer.

ACS nano·2026
Same author

Self-Organized Nanoplasmonic Artificial Leaf for Hot-Carrier Bioelectronic Interfaces.

Nature photonics·2026

Related Experiment Video

Updated: Sep 30, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.2K

Multifunctional Self-Assembly with NIR Light-Activated Cascade Effect for Improving Local Treatment on Solid Tumors.

Sirong Zhou1, Haoping Wang1, Ruipeng Li1

  • 1School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P. R. China.

ACS Applied Materials & Interfaces
|March 17, 2022
PubMed
Summary

This study introduces a novel self-assembled biomaterial that effectively eliminates solid tumors. Triggered by near-infrared light, this material enhances drug delivery and adapts to the tumor microenvironment for improved cancer treatment.

Keywords:
alkyl radicalsbiomaterialphotothermal therapyself-assemblysolid tumors

More Related Videos

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.2K
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.5K

Related Experiment Videos

Last Updated: Sep 30, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.2K
Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
08:54

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies

Published on: February 17, 2023

1.2K
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
11:20

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

7.5K

Area of Science:

  • Biomaterials Science
  • Oncology
  • Nanotechnology

Background:

  • Incomplete local treatment of solid tumors leads to metastasis and recurrence.
  • Tumor microenvironments, including dense matrices and hypoxia, limit therapeutic efficacy.
  • Improved agent infiltration and hypoxia-adapted therapies are crucial for better tumor cure rates.

Purpose of the Study:

  • To design and develop a self-assembled biomaterial with a cascade effect triggered by near-infrared light for solid tumor treatment.
  • To enhance the infiltration of therapeutic agents into tumor tissues.
  • To propose novel therapies for the complete elimination of solid tumors.

Main Methods:

  • A self-assembled biomaterial was constructed using biotin, a phase change material (PNIPAM), a photochemical agent (ATT-2), and an alkyl radical generator (AIPH).
  • Biotin served as a targeting group.
  • Near-infrared light triggered a cascade effect, inducing phase change and decomposition of alkyl radicals for tumor ablation.

Main Results:

  • The self-assembly demonstrated effective ablation of superficial and deep tumors via heat and alkyl radicals upon white light irradiation.
  • In vivo assays confirmed the biomaterial's ability to effectively eliminate local solid tumor lesions.
  • The developed biomaterial is adapted to the tumor microenvironment, enhancing therapeutic outcomes.

Conclusions:

  • The developed self-assembled biomaterial offers a promising strategy for improving solid tumor cure rates.
  • This work provides new insights into biomaterials adapted to the tumor microenvironment.
  • The study proposes a novel therapeutic approach for the complete elimination of solid tumors.