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Subiculum-BNST structural connectivity in humans and macaques.

Samuel C Berry1, Andrew D Lawrence1, Thomas M Lancaster2

  • 1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK.

Neuroimage
|March 19, 2022
PubMed
Summary

This study reveals a direct brain pathway connecting the subiculum to the bed nucleus of the stria terminalis (BNST) in humans and macaques. This pathway, crucial for stress regulation, shows moderate heritability but no link to stress levels or alcohol use.

Keywords:
Bed nucleus of the stria terminalis (BNST/BST)Diffusion Magnetic resonance imaging (dMRI)HippocampusHypothalamic pituitary adrenal (HPA) axisNon-human primates (NHP)StressSubiculum

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Area of Science:

  • Neuroscience
  • Neuroanatomy
  • Human and comparative brain imaging

Background:

  • Rodent studies suggest a subiculum-BNST pathway regulates the stress (Hypothalamic-Pituitary-Adrenal) axis.
  • This critical neural connection's presence and characteristics in humans and non-human primates remain unclear.

Purpose of the Study:

  • To characterize the subiculum-BNST pathway in macaques and humans.
  • To investigate the heritability of this pathway's microstructure.
  • To explore associations between pathway microstructure and stress/alcohol use.

Main Methods:

  • Anterograde tract-tracing in macaque monkeys.
  • In vivo diffusion MRI tractography in macaques and humans.
  • Heritability analysis using twin data.
  • Correlation analysis with self-reported stress and alcohol use.

Main Results:

  • Confirmed a direct, monosynaptic subiculum-BNST projection in macaques, primarily via the fornix.
  • Demonstrated substantial subiculum complex-BNST connectivity in both macaques and humans via diffusion MRI.
  • Found moderate heritability (h² ≈ 0.5) of the tract's microstructural properties in humans.
  • Observed no significant association between tract microstructure and perceived stress or alcohol use.

Conclusions:

  • Established a conserved subiculum-BNST neural pathway across species, crucial for stress regulation.
  • Highlighted the moderate heritability of this stress-related neural circuit.
  • Addressed a translational gap in understanding the neurocircuitry of stress regulation.