Related Experiment Video
Updated: Sep 29, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Biology of quinoline and quinazoline alkaloids
Xiao-Fei Shang1, Susan L Morris-Natschke2, Ying-Qian Liu3
1Beijing You'an Hospital, Capital Medical University, Beijing, PR China; Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, PR China; School of Pharmacy, Lanzhou University, Lanzhou, PR China.
Abstract:
Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic compounds, have attracted scientific and popular interest worldwide since the 19th century. More than 600 compounds have been isolated from nature to date. To build on our two prior reviews, we reexamined the promising molecules described in previous reports and provided updated literature on novel quinoline and quinazoline alkaloids isolated over the past 5 years. This chapter reviews and discusses 205 molecules with a broad range of bioactivities, including antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, and other effects. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.
Related Concept Videos
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
Physical Properties of Amines
Gene Regulation in Microbial Communities: Quorum Sensing
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Amines: Introduction

