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Published on: February 27, 2021
Stimuli-controllable iron oxide nanoparticle assemblies: Design, manipulation and bio-applications
Liang Ee Low1, Hui Peng Lim2, Yong Sze Ong3
1Chemical Engineering Discipline, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia; Biofunctional Molecule Exploratory (BMEX) Research Group, School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia.
Iron oxide nanoparticles (IONPs) show promise in medicine but face stability issues. Surface functionalization creates advanced IONP assemblies for improved disease diagnosis and therapy.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Materials Science
Background:
- Iron oxide nanoparticles (IONPs) are widely used in biomedical applications due to their favorable properties.
- Existing IONPs suffer from poor stability, low diagnostic sensitivity, and low disease specificity, limiting their clinical efficacy.
- Surface functionalization is a key strategy to enhance IONP performance and overcome current limitations.
Purpose of the Study:
- To review the design and stimuli-driven manipulation of biocompatible and stable IONP assemblies.
- To discuss the application of IONP assemblies in disease diagnosis, therapy, and imaging-guided treatments.
- To comment on the challenges and future prospects of IONP assemblies in biomedical utilization.
Main Methods:
- Review of literature on IONP assembly design and functionalization strategies.
- Analysis of stimuli-responsive mechanisms for IONP manipulation.
- Discussion of current and potential applications in disease diagnosis and therapy.
Main Results:
- Biocompatible and stable IONP assemblies can be designed through surface functionalization.
- These assemblies offer improved colloidal stability and circulation time.
- IONP assemblies enable multi-responsive and disease-targetable delivery for enhanced diagnostics and therapeutics.
Conclusions:
- Surface functionalization is crucial for developing advanced IONP assemblies with improved biomedical performance.
- IONP assemblies hold significant potential for accurate and efficient disease diagnosis and therapy.
- Further research into IONP assemblies could lead to breakthroughs in multi-responsive nanomedicine.
