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Clinical, Endoscopic, and Histopathology Features of Esophageal Graft-vs-Host Disease

Amrit K Kamboj¹, Siddharth Agarwal¹, Manoj K Yarlagadda¹

¹Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

The American Journal of Gastroenterology

|March 21, 2022

Introduction:

To describe the clinical, endoscopic, and histopathology features of esophageal graft-vs-host disease (GVHD).

Methods:

Patients with biopsy-proven esophageal GVHD diagnosed at Mayo Clinic between 2000 and 2021 were included.

Results:

In 43 esophageal patients, other organ GVHD was present in 58% before and 86% at esophageal GVHD diagnosis. Esophageal specific symptoms were uncommon (dysphagia 26% and odynophagia/heartburn 5%). Esophagogastroduodenoscopy was abnormal in 72% patients demonstrating erosive esophagitis, ulceration, desquamation, or rings/furrows in a diffuse or focal pattern.

Discussion:

There should be a low threshold for esophageal biopsies for GVHD because esophageal symptoms and endoscopic findings may be nonspecific or absent.

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