Histopathological changes of lymphatic malformation after bleomycin injection
Yasser H Al-Faky1, Hind Manaa Alkatan1,2
1Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Arquivos Brasileiros De Oftalmologia
|March 23, 2022
Summary
Intralesional bleomycin injection effectively treats eyelid lymphatic malformations by inducing fibrosis. This minimally invasive approach offers favorable outcomes and reduces surgical complications for orbital tumors.
Area of Science:
- Ophthalmology
- Vascular Anomalies
- Pathology
Background:
- Lymphatic malformation is a rare orbital tumor historically treated with high-complication surgery.
- Intralesional bleomycin injection has emerged as a recent alternative treatment.
- This case details histopathological changes following bleomycin treatment for eyelid lymphatic malformation.
Discussion:
- The study confirms fibrosis induction by water-soluble intralesional bleomycin injection.
- Histopathological analysis revealed fibrotic changes in the lymphatic malformation.
- This supports bleomycin's efficacy in treating orbital lymphatic malformations.
Key Insights:
- Intralesional bleomycin injection leads to significant fibrosis in lymphatic malformations.
- This treatment resulted in easier surgical intervention with minimal bleeding.
- The patient experienced no recurrence and achieved favorable aesthetic results.
Outlook:
- Intralesional bleomycin offers a promising, less invasive treatment for orbital lymphatic malformations.
- Further research into bleomycin's long-term effects and optimal dosing is warranted.
- This approach may reduce the need for complex surgical debulking in pediatric and adult cases.
