Related Experiment Video
Updated: Sep 29, 2025
07:30
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
3.2K
[Association between cardiometabolic risk and cognitive impairment]
Luciana Sepúlveda-Pezoa1, Daniela Gómez-Pérez2, Manuel S Ortiz1
1Laboratorio de Estrés y Salud, Facultad de Educación, Ciencias Sociales y Humanidades, Universidad de La Frontera, Temuco, Chile.
Revista Medica De Chile
|March 23, 2022
Summary
Cardiometabolic risk factors directly impact cognitive functioning in adults. Cognitive reserve did not mediate this relationship in this study, suggesting a direct link between metabolic health and brain function.
Area of Science:
- Gerontology
- Neuroscience
- Cardiology
Background:
- Cognitive impairment in older adults is linked to various risk factors.
- The role of cardiometabolic variables and cognitive reserve in this association requires further investigation.
Purpose of the Study:
- To examine the association between cardiometabolic risk factors and cognitive functioning.
- To determine if cognitive reserve mediates the relationship between cardiometabolic risk factors and cognitive functioning.
Main Methods:
- A cross-sectional study involving 300 participants (median age 56 years, 53% male).
- Cognitive functioning was assessed.
- Key cardiometabolic variables including fasting glucose, HDL-cholesterol, and blood pressure were measured.
Main Results:
- Cardiometabolic risk factors showed a direct negative effect on cognitive functioning (β = -.204; p = .056).
- Cognitive reserve was positively associated with cognitive functioning (β = .327; p = .01).
- Cognitive reserve did not significantly mediate the association between cardiometabolic risk factors and cognitive functioning (β = .077; p = .07).
Conclusions:
- Cardiometabolic risk factors have a direct detrimental effect on cognitive functioning.
- Cognitive reserve does not appear to mediate this direct association.
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