Tweaking neural organoids to model human reactive astrocytes
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Updated: Sep 29, 2025
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Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells
Published on: August 16, 2018
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Paola Bezzi1,2
1Department of Fundamentals Neurosciences, UNIL, Lausanne, Switzerland.
The Journal of Cell Biology
|March 23, 2022
Abstract:
The study of human reactive astrocytes has been limited by resource availability. In this issue, Cvetkovic et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202107135) develop multicellular organoid systems containing mature astrocytes to study the dynamics of human astrocytes reactivity and its downstream effects on neuronal activity.
