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Auditing the Editor: A Review of Key Translational Issues in Epigenetic Editing
Katherine Huerne1, Nicole Palmour1, Angela Ruohao Wu2,3
1Centre of Genomics and Policy, McGill University, Montreal, Canada; Ulm University and Ulm University Medical Center, Ulm, Germany.
Abstract:
Currently, most advances in site-specific epigenetic editing for human use are concentrated in basic research, yet, there is considerable interest to translate this technology beyond the bench. This review highlights recent developments with epigenetic editing technology in comparison with the canonical CRISPR-Cas genome editing, as well as the epistemic and ethical considerations with preemptive translation of epigenetic editing into clinical or commercial use in humans. Key considerations in safety, equity, and access to epigenetic editing are highlighted, with a spotlight on the ethical, legal, and social issues of this technology in the context of global health equity.
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