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FER1L4: A Long Non-coding RNA with Multiple Roles in the Occurrence and Development of Tumors

Jie Mou1, Bei Wang1, Yuling Liu1

  • 1Medical College, China Three Gorges University, Yichang 443002, China.

Current Pharmaceutical Design
|March 25, 2022
PubMed
Abstract

Insights

Long non-coding RNA FER1L4 (FER1L4) is crucial in various cancers. This review summarizes FER1L4's role as a tumor suppressor or oncogene, impacting tumor progression and offering diagnostic and therapeutic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • FER-1 family member 4 (FER1L4) is a long non-coding RNA (lncRNA) with significant biological functions in diverse tumor types.
  • Located at 20q11.22, FER1L4's role in tumorigenesis is increasingly recognized.

Purpose of the Study:

  • To elucidate the pathophysiological mechanisms of FER1L4 in various cancers.
  • To review the potential biological functions of FER1L4 across different tumor contexts.

Main Methods:

  • Comprehensive literature search conducted on PubMed.
  • Systematic review and summarization of existing research on FER1L4's role in tumorigenesis.

Main Results:

  • FER1L4 is frequently downregulated in numerous cancers, acting as a tumor suppressor.
  • Conversely, FER1L4 is upregulated in specific cancers like breast cancer and glioma, functioning as an oncogene.
  • FER1L4 influences critical cancer processes including proliferation, invasion, migration, and apoptosis.

Conclusions:

  • LncRNA FER1L4 demonstrates dual roles as a tumor suppressor and oncogene.
  • FER1L4 exhibits significant potential for diagnostic and therapeutic applications in oncology.
Keywords:
FER1L4Long non-coding RNAbiological markerdiagnosismalignancymechanismprognosistarget

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