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Updated: Sep 28, 2025

Picometer-Precision Atomic Position Tracking through Electron Microscopy
Published on: July 3, 2021
Exploring Blob Detection to Determine Atomic Column Positions and Intensities in Time-Resolved TEM Images with
Ramon Manzorro1, Yuchen Xu2, Joshua L Vincent1
1School for the Engineering of Matter, Transport, and Energy, Arizona State University, Engineering G Wing #301, 501 E Tyler Mall, Tempe, AZ85287, USA.
We developed a novel blob detection method to analyze noisy transmission electron microscopy (TEM) images. This technique accurately tracks atomic column positions and intensities in dynamic nanomaterials.
Area of Science:
- Materials Science
- Electron Microscopy
- Image Analysis
Background:
- In situ transmission electron microscopy (TEM) with direct electron detection enables millisecond temporal resolution for atom-scale dynamics.
- High temporal resolution in TEM imaging leads to poor signal-to-noise ratios, complicating the analysis of atomic column positions and intensities.
- Characterizing fluxional behavior in materials at the atomic scale is challenging due to image noise.
Purpose of the Study:
- To develop a robust image processing approach for analyzing high-noise, high-temporal-resolution TEM image series.
- To improve the precision of determining atomic column position and intensity in dynamic nanomaterials.
- To adapt computer vision techniques for advanced materials characterization.
Main Methods:
- Implementation of a noise-robust blob detection algorithm tailored for TEM image series.
- Application of the blob detection method to noisy images of nanoparticle systems.
- Comparison of the blob detection approach with existing algorithms for image analysis.
Main Results:
- The proposed blob detection method effectively handles high noise content in TEM images.
- The algorithm outperforms other methods in determining atomic column position and intensity.
- Enhanced precision in analyzing atom-scale dynamics of materials is achieved.
Conclusions:
- Blob detection offers a superior solution for processing noisy TEM data, particularly for dynamic systems.
- This approach facilitates more accurate characterization of atomic-scale material behavior.
- The method advances the capabilities of in situ TEM for studying materials dynamics.
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