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Retinal imaging with optical coherence tomography in multiple sclerosis: novel aspects.
Elisabeth Olbert1,2, Walter Struhal3,4
1Department of Neurology, University Hospital Tulln, Alter Ziegelweg 10, 3430, Tulln an der Donau, Austria. elisabeth.olbert@tulln.lknoe.at.
Wiener Medizinische Wochenschrift (1946)
|March 29, 2022
Summary
Optical coherence tomography (OCT) can track retinal layer thinning in multiple sclerosis (MS) patients, reflecting disease progression and impacting clinical outcomes. Further research is needed for its integration into standard MS care.
Area of Science:
- Ophthalmology and Neurology
- Neuroimmunology
Background:
- Optical coherence tomography (OCT) is gaining clinical relevance for multiple sclerosis (MS) assessment.
- OCT provides insights into the pathophysiology of MS by documenting retinal changes.
Approach:
- This narrative review discusses novel OCT parameter changes in acute optic neuritis and MS disease course.
- Analysis of retinal layer thinning, accelerated by relapses and progression, is central.
Key Points:
- OCT parameters correlate with clinical outcomes like disability, cognitive function, and brain atrophy.
- Retinal layer thinning progresses throughout the MS disease course, influenced by relapses and progression.
- Disease-modifying therapies' impact on OCT parameters is under investigation and varies by agent.
Conclusions:
- OCT offers valuable insights into MS pathophysiology and disease progression.
- OCT parameters show association with key clinical outcomes in MS patients.
- More data are required to establish OCT parameters as a clinical standard for MS care.
