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Updated: Sep 28, 2025

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
Neoadjuvant Therapy for Rectal Cancer
Felipe F Quezada-Diaz1, J Joshua Smith2
1Colorectal Unit, Department of Surgery, Complejo Asistencial Doctor Sótero del Río, Avenida Concha y Toro#3459, Santiago, Puente Alto, RM 8207257, Chile. Electronic address: https://twitter.com/ffquezad.
Abstract:
The treatment of locally advanced rectal cancer is challenging and requires a multidisciplinary approach. Neoadjuvant treatment has improved local control by the combination of radiotherapy, surgery, and chemotherapy. However, neoadjuvant treatment has not yet been shown to improve overall survival and is associated with toxicities and late sequelae that impair the quality of life of patients. Currently, different types of neoadjuvant strategies have raised the question about which one is the optimal strategy for rectal cancer treatment. In this article, we explore the different neoadjuvant treatment regimens currently available, their associated benefits and toxicities, and novel approaches in this area.
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