Hybrid modelling of biological systems: current progress and future prospects
Related Experiment Video
Updated: Sep 28, 2025

A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression
Published on: October 6, 2019
Fei Liu1, Monika Heiner2, David Gilbert3
1School of Software Engineering, South China University of Technology, Guangzhou 510006, P.R. China.
Abstract:
Integrated modelling of biological systems is becoming a necessity for constructing models containing the major biochemical processes of such systems in order to obtain a holistic understanding of their dynamics and to elucidate emergent behaviours. Hybrid modelling methods are crucial to achieve integrated modelling of biological systems. This paper reviews currently popular hybrid modelling methods, developed for systems biology, mainly revealing why they are proposed, how they are formed from single modelling formalisms and how to simulate them. By doing this, we identify future research requirements regarding hybrid approaches for further promoting integrated modelling of biological systems.
Related Concept Videos
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Hybridoma Technology
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
Model Approaches for Pharmacokinetic Data: Physiological Models
Mechanistic Models: Compartment Models in Individual and Population Analysis
Two-Compartment Open Model: Overview
The...
Pharmacokinetic Models: Comparison and Selection Criterion
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.

