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Single-Stranded DNA-Encoded Gold Nanoparticle Clusters as Programmable Enzyme Equivalents.

Xiaoliang Chen¹, Yue Wang^2,3, Xinpei Dai²

¹School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Journal of the American Chemical Society

|March 30, 2022

Summary

Researchers developed a DNA-based method to precisely organize gold nanoparticle clusters (GNCs) into programmable enzyme equivalents (PEEs). This approach enables tunable catalytic activity for nanozyme applications.

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Area of Science:

Nanotechnology
Biotechnology
Materials Science

Background:

Nanozymes offer a promising alternative to natural enzymes due to their stability and cost-effectiveness.
Controlling the spatial arrangement of nanomaterials within nanozymes is crucial for optimizing their catalytic functions, but remains a significant challenge.

Purpose of the Study:

To develop a DNA-based strategy for precisely encoding the organization of gold nanoparticle clusters (GNCs).
To construct programmable enzyme equivalents (PEEs) with tunable catalytic properties.

Main Methods:

Utilizing single-stranded DNA scaffolds that self-fold into nanostructures with specific poly-adenine (polyA) loops and double-stranded stems.
Employing polyA loops for seed-free nucleation and controlled growth of GNCs with defined particle numbers and interparticle spacing.
Synthesizing a range of GNCs, from oligomers to polymer-like chains, in situ.

Main Results:

Demonstrated the formation of GNCs with precise control over particle number and spatial arrangement using DNA scaffolds.
Showcased that polymeric GNCs exhibit programmable peroxidase-like catalytic activity.
Established that catalytic activity can be tuned by altering scaffold size and inter-polyA spacer length.

Conclusions:

The DNA-based approach provides a versatile platform for the rational design and construction of complex nanozyme architectures.
This method facilitates the engineering of programmable enzyme equivalents with tailored catalytic functionalities.
Opens new avenues for developing advanced nanozymes for diverse biological and biomedical applications.