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Association of Primary Open-angle Glaucoma With Tinnitus: A Nationwide Population-Based Study
Tung-Mei Kuang1,2,3, Sudha Xirasagar4, Yen-Fu Cheng5,6,7
1Departments of Ophthalmology.
Journal of Glaucoma
|March 30, 2022
Summary
Tinnitus is linked to a higher risk of developing primary open-angle glaucoma (POAG). This population-based study highlights a significant association between POAG and tinnitus, urging clinical awareness.
Area of Science:
- Ophthalmology
- Otorhinolaryngology
- Epidemiology
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Tinnitus, the perception of sound without an external source, affects a significant portion of the population.
- The relationship between POAG and tinnitus requires further investigation.
Purpose of the Study:
- To investigate the association between primary open-angle glaucoma (POAG) and tinnitus.
- To determine if patients with POAG have an increased risk of developing tinnitus.
Main Methods:
- A nationwide population-based case-control study utilizing data from Taiwan's National Health Insurance Research Database.
- Inclusion of 542,682 patients diagnosed with tinnitus (cases) and 1,628,046 propensity score-matched controls.
- Multiple logistic regression analysis was performed to assess the odds of prior POAG in cases versus controls, adjusting for various demographic and health factors.
Main Results:
- A significant association was found between prior primary open-angle glaucoma (POAG) and tinnitus (adjusted OR=1.298).
- The prevalence of POAG was higher in patients with tinnitus (4.70%) compared to controls (3.67%).
- The association remained significant after adjusting for multiple confounding variables.
Conclusions:
- Patients with primary open-angle glaucoma (POAG) exhibit an elevated risk of tinnitus.
- Ophthalmologists should consider this association in clinical practice.
- Further research is warranted to elucidate the underlying pathophysiological mechanisms connecting POAG and tinnitus.
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