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Network-based approaches for the investigation of microbial community structure and function using metagenomics-based
Thomas Kaiser1,2, Cyrus Jahansouz1, Christopher Staley1,2
1Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
Future Microbiology
|April 1, 2022
Summary
Network analysis helps understand microbial communities and their environmental roles. This perspective explores network construction and interpretation for host-microbiota interactions, addressing challenges in translational science.
Area of Science:
- Microbial ecology
- Systems biology
- Network science
Background:
- Network-based approaches are crucial for understanding microbial community organization and function.
- Network theory is emerging as a key method for integrating 'omics' data within systems biology.
- Complexities in network construction hinder the application of these tools in translational science.
Purpose of the Study:
- To provide a perspective on network construction methods.
- To discuss network interpretation strategies.
- To highlight emerging applications in host-microbiota interaction research.
Main Methods:
- Review of network construction methodologies.
- Discussion of network interpretation principles.
- Exploration of systems biology and 'omics' data integration.
Main Results:
- Identification of challenges in network theory application.
- Overview of current network construction and interpretation techniques.
- Examples of network analysis in host-microbiota studies.
Conclusions:
- Network approaches offer valuable insights into microbial ecology.
- Addressing methodological and computational complexities is vital for translational applications.
- Further development is needed to fully leverage network theory for understanding complex biological systems like host-microbiota interactions.
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