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Updated: Sep 28, 2025
In vivo Optogenetic Stimulation of the Rodent Central Nervous System
Published on: January 15, 2015
Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region
Kelly C Y Wong1, Ellen M Sletten1
1Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California, 90095, United States.
Abstract:
Fluorescence imaging is an indispensable method for studying biological processes non-invasively in cells and transparent organisms. Extension into the shortwave infrared (SWIR, 1000-2000 nm) region of the electromagnetic spectrum has allowed for imaging in mammals with unprecedented depth and resolution for optical imaging. In this review, we summarize recent advances in imaging technologies, dye scaffold modifications, and incorporation of these dyes into probes for SWIR imaging in mice. Finally, we offer an outlook on the future of SWIR detection in the field of chemical biology.
