Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fatal rabies in a child.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne·2026
Same author

Biosurveillance and early outbreak detection of rabies in settings with limited laboratory capacity using spatiotemporal clustering and a machine learning framework.

Scientific reports·2026
Same author

Barriers to Canine Rabies Vaccination in Nigeria: Implications for Rabies Elimination by 2030.

Zoonoses and public health·2026
Same author

Wildlife Rabies Virus Dynamics in Alabama, USA, 2020-25.

Journal of wildlife diseases·2026
Same author

Delivery of canine rabies vaccination programme in Kutupalong-Balukhali refugee camps, Cox's Bazar, Bangladesh.

PLoS neglected tropical diseases·2026
Same author

Rabies and Pinnipeds Reviewed: Premonitions, Perturbations, and Projections?

Veterinary sciences·2026
Same journal

Biphasic tissue expression of cfa-miR-409-3p and cfa-miR-4270 during malignant transformation in canine mammary tumors: an exploratory study.

Frontiers in veterinary science·2026
Same journal

Adjunctive use of a collagen membrane for surgical closure of oronasal fistulae in dogs with challenging local conditions: a case series.

Frontiers in veterinary science·2026
Same journal

Multi-QuadEmoNet: cat and dog emotion classification model from animal vocalization using multi-stage LSTM-GRU paradigm.

Frontiers in veterinary science·2026
Same journal

Effects of sodium butyrate on the morphology, antioxidant capacity, mitochondrial integrity, and the transcriptome of the jejunum in early weaned lambs.

Frontiers in veterinary science·2026
Same journal

The first complete mitochondrial genome sequences of <i>Neopsylla specialis dechingensis</i> and <i>Neopsylla stevensi sichuanyunnana</i>, with an assessment of their phylogenetic placement.

Frontiers in veterinary science·2026
Same journal

Compartment-specific immune responses to BoAHV-1 transplacental infection in late gestation.

Frontiers in veterinary science·2026
See all related articles

Related Experiment Video

Updated: Sep 28, 2025

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.3K

A One Medicine Mission for an Effective Rabies Therapy.

Darryn L Knobel1,2,3, Alan C Jackson4,5, John Bingham6

  • 1Department of Biomedical Sciences, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis.

Frontiers in Veterinary Science
|April 4, 2022
PubMed
Summary
This summary is machine-generated.

Developing a rabies treatment requires a One Medicine approach. Investigating therapies in naturally infected dogs can accelerate progress against this dire viral disease.

Keywords:
blood-brain barriercanineimmunotherapyneurodegenerationpathogenesisprognosisrabiestreatment

More Related Videos

A Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies
04:10

A Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies

Published on: November 29, 2024

985
Field Postmortem Rabies Rapid Immunochromatographic Diagnostic Test for Resource-Limited Settings with Further Molecular Applications
07:40

Field Postmortem Rabies Rapid Immunochromatographic Diagnostic Test for Resource-Limited Settings with Further Molecular Applications

Published on: June 29, 2020

13.8K

Related Experiment Videos

Last Updated: Sep 28, 2025

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.3K
A Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies
04:10

A Trap-Vaccinate-Release Protocol for Immunization of Skunks and Additional Rabies Vectors Against Rabies

Published on: November 29, 2024

985
Field Postmortem Rabies Rapid Immunochromatographic Diagnostic Test for Resource-Limited Settings with Further Molecular Applications
07:40

Field Postmortem Rabies Rapid Immunochromatographic Diagnostic Test for Resource-Limited Settings with Further Molecular Applications

Published on: June 29, 2020

13.8K

Area of Science:

  • Veterinary Medicine
  • Infectious Diseases
  • Neurology

Background:

  • Rabies remains a significant global health threat with a dire prognosis and limited treatment options.
  • Developing effective rabies therapies is challenging due to sporadic cases and the high cost/expertise required for critical care.

Purpose of the Study:

  • To advocate for a One Medicine approach to accelerate rabies treatment development.
  • To explore the potential of using naturally infected dogs in research to study combination therapies.

Main Methods:

  • Reviewing rabies pathogenesis in humans and dogs, including molecular mechanisms of neurological dysfunction.
  • Proposing management strategies for viral propagation, neuronal degeneration, inflammation, and systemic compromise.
  • Suggesting compassionate critical care and investigational treatment for naturally infected dogs.

Main Results:

  • Identified four key disease processes to manage in rabies patients: viral propagation, neuronal degeneration, inflammation, and systemic compromise.
  • Proposed that treating naturally infected dogs can provide opportunities to study combination therapies and identify biomarkers.
  • Discussed the safety and ethical considerations of this One Medicine approach.

Conclusions:

  • A One Medicine approach, utilizing veterinary care for naturally infected dogs, can accelerate the development of effective rabies treatments.
  • The Canine Rabies Treatment Initiative aims to advance diagnostic, prognostic, and therapeutic options for rabies.
  • Transforming rabies into a treatable disease for all patients is the ultimate goal.