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Updated: Sep 28, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Innate Immune Subversion Strategies of Human Flaviviruses
Sumandeep Kaur1, Shashank Tripathi2
1Emerging Viral Pathogens Lab, Centre for Infectious Disease Research, Indian Institute of Science, Bangalore, India 560012; Microbiology & Cell Biology Department, Biological Sciences Division, Indian Institute of Science, Bangalore, India 560012.
Abstract:
Flavivirus is a genus of medically important viruses, including Dengue virus (DENV), Zika virus (ZIKV), Yellow Fever virus (YFV), West Nile virus (WNV), Japanese encephalitis virus (JEV), etc. The global burden of these acute infection-causing viruses is ever-increasing. Primary febrile symptoms of most of these viruses can progress to hemorrhagic or neurological complications, and some like JEV, YFV have a greater than 15% mortality. The absence of antiviral therapy and highly effective vaccine candidates for these viruses highlights the need for research into virulence and immune evasion mechanisms at the molecular level. Interaction with the host needs to be carefully dissected to narrow down to a list of necessary factors for virus survival within the host. This review attempts to comprehensively compile research efforts made in the field of innate immune subversion strategies employed by the human Flaviviruses.
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