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Adipose tissue aging: mechanisms and therapeutic implications.
Min-Yi Ou1, Hao Zhang1, Poh-Ching Tan1
1Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 200011, Shanghai, China.
Cell Death & Disease
|April 5, 2022
Summary
Aging significantly alters adipose tissue, impacting energy balance and leading to age-related diseases like type 2 diabetes. Targeting adipose tissue aging may offer therapeutic strategies for healthier aging.
Area of Science:
- Gerontology
- Metabolic Science
- Endocrinology
Background:
- Adipose tissue is vital for energy homeostasis and acts as an endocrine organ.
- Aging causes significant changes in adipose tissue, contributing to physiological decline and disease in the elderly.
- These age-related adipose tissue changes are linked to metabolic disorders and inflammation.
Purpose of the Study:
- To review age-related changes in adipose tissue at multiple levels.
- To highlight mechanisms regulating adipose tissue aging.
- To discuss pathogenic pathways of fat dysfunction and their systemic consequences.
Main Methods:
- Review of scientific literature on adipose tissue aging.
- Analysis of age-related changes in adipose tissue composition and function.
- Examination of molecular and cellular mechanisms involved in adipose aging.
Main Results:
- Adipose tissue aging involves deposit redistribution, progenitor cell decline, and senescent cell accumulation.
- Pathogenic pathways lead to impaired adipogenesis, inflammation, and insulin resistance.
- Adipose aging accelerates systemic inflammation, metabolic disruption, and overall aging.
Conclusions:
- Adipose tissue dysfunction is a key factor in aging and age-related diseases.
- Targeting adipose tissue aging presents a potential therapeutic strategy for extending lifespan and treating metabolic diseases.
- Further research into adipose tissue aging is crucial for advancing knowledge and developing interventions.
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