Related Experiment Video
Updated: Sep 27, 2025
07:17
An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
11.1K
Pancreatic Carcinoid Tumor in a Pediatric Patient
Dania Ibrahim Musalli1, Yasser Ali Binafif1, Abeer M Mirdad1
1Department of Pediatrics, East Jeddah General Hospital, Jeddah, Saudi Arabia.
The American Journal of Case Reports
|April 8, 2022
Summary
A rare pediatric case highlights incidental pancreatic carcinoid tumors causing Cushing syndrome. Early investigation of hypertension in children is crucial for diagnosing rare endocrinopathies and potential malignancy.
Area of Science:
- Pediatric Endocrinology
- Surgical Oncology
- Neuroendocrine Tumors
Background:
- Carcinoid tumors, rare neuroendocrine neoplasms, typically arise in the GI tract or lungs.
- Pancreatic carcinoid tumors are uncommon, sometimes associated with Multiple Endocrine Neoplasia type 1 (MEN1).
- Cushing syndrome in children necessitates thorough investigation for underlying causes.
Observation:
- A 9-year-old girl presented with Cushing syndrome symptoms including hypertension, fatigue, and skin changes.
- Incidental diagnosis of a pancreatic carcinoid tumor was made based on clinical presentation and imaging.
- The patient underwent surgical resection (distal pancreatectomy and splenectomy).
Findings:
- Histopathology confirmed a well-differentiated neuroendocrine tumor (G2).
- Concurrent Cushing syndrome and carcinoid syndrome presented a diagnostic challenge due to rarity.
- Screening for MEN syndrome is vital in pediatric Cushing syndrome due to malignancy risk.
Implications:
- Incidental hypertension in children warrants investigation for endocrinopathies like Cushing and carcinoid syndromes.
- This case underscores the importance of reporting rare pediatric neuroendocrine tumor presentations.
- Further case reports are needed to expand understanding and management strategies for these rare conditions.
