[Brain damage in sleep-disordered breathing: the role of glia (clinical aspects)]
I A Filchenko1, L S Korostovtseva2, M V Bochkarev2
1Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, St. Petersburg, Russia.
Abstract:
Sleep-disordered breathing (SDB) is one of the most frequent sleep-wake disorders. SDB is associated with brain damage that manifests as structural (atrophy of amygdala, hippocampus, insula) and functional (cognitive and emotional dysfunction) disorders. In this review, we summarize the results of clinical and experimental studies investigating the approach for the decreasing brain damage in SDB via glial modulation. In conclusion, we suggest the strategies for future research aimed at optimizing diagnostics and treatment of brain damage in SDB.
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