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Published on: October 6, 2023
Snakebite envenomation in children: An ongoing burden in Morocco
Meryem Essafti1, Mohamed Fajri1, Chadi Rahmani1
1Anesthesia and Critical Care Department, Pediatric Intensive Care Unit, CHU Mohamed VI, Marrakesh, Morocco.
Insights
Snakebite management in Moroccan children improved with a national protocol, including antivenom therapy. Early treatment significantly reduced complications and hospital stays, though prevention remains crucial.
Area of Science:
- Pediatric intensive care
- Toxicology
- Public health
Background:
- Snakebites are a major cause of mortality and disability in children, particularly in tropical regions like Morocco.
- A national protocol was implemented to reduce snakebite morbimortality through antivenom therapy and prevention.
Purpose of the Study:
- To describe clinical aspects of pediatric snakebite envenomation before and after protocol implementation.
- To evaluate the impact of the national protocol on snakebite management outcomes in children.
Main Methods:
- Retrospective study of 75 children admitted to the pediatric intensive care unit (PICU) in Marrakesh over 11 years.
- Analysis of clinical data, envenomation severity, complications, and treatment outcomes, including antivenom administration.
Main Results:
- Most envenomations occurred during outdoor activities, with altered hemostasis (67%) and local symptoms being common.
- Antivenom administration significantly improved hemostasis, reduced need for transfusions and fasciotomy, and shortened PICU stay.
- Acute kidney injury occurred in 18 cases but mostly resolved within 48 hours; five children died, two with delayed antivenom.
Conclusions:
- Specific serotherapy optimizes snakebite management, preventing and treating local and systemic complications.
- Primary prevention strategies are essential for further reducing snakebite morbimortality in children.
Introduction:
Snakebites are a leading cause of mortality and permanent disabilities especially among children in tropical countries and rural areas such as Morocco. Thus, a nationwide management protocol including specific antivenom therapy along with prevention strategies was implemented to reduce the overall snakebites morbimortality.
Patients And Methods:
Our retrospective study aimed to describe the clinical aspects of snakebite envenomation before and after the implementation of this protocol in children admitted to the pediatric intensive care unit (PICU) in Marrakesh-Morocco for a period of 11 years.
Results:
A total of 75 cases were included and were mostly male (70%) with a mean age of 10 years old. Most envenomations were mild or severe (75%) and often occurred during outdoor activities in limb extremities. Altered hemostasis frequently occurred in 67% of cases but was rarely associated with severe exteriorized hemorrhage. Moderate anemia and PNN- predominant leukocytosis were often observed at admission (52.2% and 58%) but quickly tended to normalize before 48 h. Local symptoms were the main dread as they quickly evolve to a compartment syndrome and necrosis in the absence of antivenom therapy. Fasciotomy was performed in 33% of cases while 5 children required limb amputation. Antivenom administration (n = 39) was statistically significant for rapid improvement in hemostasis disorders, reduced blood transfusions and fasciotomy for compartment syndrome as well as a shortened length of stay in PICU. The onset of acute kidney injury was observed in 18 cases but restored in most patients within 48 h (77%). Five children died of which only two had received delayed antivenom immunotherapy due to its unavailability and deferred hospital admission.
Conclusion:
The advent of specific serotherapy has made it possible to optimize the management of patients and to prevent and treat local and systemic complications thus improving the overall prognosis; nevertheless, primary prevention remains the key to reducing snakebites morbimortality.
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