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Disorders of the Skeletal Muscle01:28

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Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
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Neuromyotonia: a skin-deep problem.

François Maurier1, Maud Michaud2, Roxane Reviron3

  • 1Médecine Interne, Hopitaux Prives de Metz, Metz, France francois.maurier@hp-metz.fr.

BMJ Case Reports
|April 12, 2022
PubMed
Summary
This summary is machine-generated.

Neuromyotonia (NMT), a rare neurological disorder, can manifest as debilitating muscle cramps and twitching. This case highlights NMT as a potential complication of morphea, a skin condition.

Keywords:
dermatologymotor neurone diseaseperipheral nerve disease

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Area of Science:

  • Neurology
  • Dermatology
  • Immunology

Background:

  • Morphea is a localized sclerosing skin disorder.
  • Neuromyotonia (NMT) is a rare disorder characterized by abnormal muscle excitability.

Observation:

  • A 45-year-old woman presented with scar-like skin lesions post-mammoplasty, later developing severe cramps and involuntary movements.
  • Clinical and electromyographic findings confirmed neuromyotonia in the affected limb.

Findings:

  • Skin lesions were diagnosed as morphea.
  • Neuromyotonia was diagnosed based on clinical presentation and electromyography showing high-frequency motor unit potentials.
  • Autoimmune markers were present, but specific antibodies for NMT were negative.

Implications:

  • This case suggests neuromyotonia is a rare, debilitating neurological complication of morphea.
  • Combined treatment with antiepileptics for NMT and immunosuppressants for morphea was initiated.
  • Further research into the link between morphea and NMT is warranted.