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Comparative Lesions Analysis Through a Targeted Sequencing Approach
Published on: November 5, 2019
Search and sequence analysis tools services from EMBL-EBI in 2022.
Fábio Madeira1, Matt Pearce1, Adrian R N Tivey1
1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Nucleic Acids Research
|April 12, 2022
Summary
The European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI) offers integrated search and sequence analysis tools. Recent updates enhance these services for large-scale data, including during the COVID-19 pandemic.
Area of Science:
- Bioinformatics
- Computational Biology
- Genomic Data Analysis
Background:
- The European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI) provides essential data resources and bioinformatics tools.
- Access to these resources is crucial for biological research and data analysis.
Purpose of the Study:
- To describe recent improvements to EMBL-EBI's search and sequence analysis tools.
- To highlight updates made to support increasing data demands, particularly during the COVID-19 pandemic.
Main Methods:
- Utilizing the EBI Search full-text engine for over 5 billion entries.
- Employing the Job Dispatcher tools framework for diverse sequence analysis.
- Providing access via web applications and APIs (RESTful and SOAP).
Main Results:
- Enhanced integrated access to EMBL-EBI's data and analytical tools.
- Improved capacity to handle large-scale datasets, exemplified by COVID-19 data requirements.
- Continued support for the scientific community through user-friendly interfaces and robust APIs.
Conclusions:
- The EMBL-EBI search and sequence analysis frameworks are vital for modern biological research.
- Ongoing development ensures these tools remain effective and scalable for evolving scientific needs.
- Updates facilitate efficient data handling and analysis, crucial for global health challenges.

