IMPACT OF MICROBIOME COMPOSITION ON QUALITY OF LIFE IN HEMODIALYSIS PATIENTS

Accumulating evidence showed that chronic inflammation is a risk factor for increased cardiovascular mortality in the population with Kidney Failure (KF) remaining on Kidney Replacement Therapy (KRT). The gut microbiome is altered in patients with Chronic Kidney Disease (CKD) and is one of the major sources of chronic inflammation. Uremic gut microbiome may have serious effects on patients' quality of life (QoL) and, especially, on their psychological, social, and economic prosperity. Factors that influence health-related quality of life (HRQOL) in patients with ESRD have received little attention. Aim - this study aimed to investigate changes of QOL in HD patients by the correction of intestinal microflora. The sample study consisted of 33 HD patients (age 18-75) from "The clinical center for development of nephrology". Data was collected through the completion of a specially designed questionnaire. For assessment of Qo was used the "Missoula VITAS Quality of life index. Fecal samples were analyzed before and after treatment with probiotics. It was revealed alteration of the colonic microbial composition in the sample of the hemodialysis patients. Also, there was a strict correlation between gut dysbiosis and HD patients' QoL. Our study demonstrates important relationships between gut dysbiosis and QoL in HD patients. Correction of intestinal flora with probiotics-containing L. acidophilus, B. longum, and S. Thermophilus for a long period of at least 12 weeks improves the quality of their lives.