Related Experiment Video
Updated: Sep 27, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Recent advances and prospects in the Zn-catalysed Mannich reaction
Salahudeen Shamna1, C M A Afsina1, Rose Mary Philip1
1School of Chemical Sciences, Mahatma Gandhi University Priyadarsini Hills Kottayam Kerala 686560 India anilgi1@yahoo.com anil@mgu.ac.in +91-481-273-1036.
Abstract:
Zn-catalysed reactions are ubiquitously important due to their inexpensive, generally less toxic and atom-economic nature. According to the modern criteria of sustainability, their use in a catalytic manner is a highly desirable goal, especially when using chiral ligands. Considering the relevance of well-established zinc-mediated C-C bond formation reactions, it is relatively surprising that the use of Zn as a catalyst is still underdeveloped, especially in comparison with other transition metals. The vast majority of natural molecules, including proteins, nucleic acids and most biologically active compounds, contain nitrogen. Consequently, developing new synthetic methods for the construction of nitrogenous molecules receives great attention from organic chemists. The Mannich reaction is a very basic and very useful platform for the development of several such nitrogen-containing molecules. In this review, we summarise the recent advancements in the Zn-catalysed Mannich reaction, covering the literature from 2011 to 2020.
More Related Videos
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
09:45Accessing Valuable Ligand Supports for Transition Metals: A Modified, Intermediate Scale Preparation of 1,2,3,4,5-Pentamethylcyclopentadiene
Published on: March 20, 2017
Related Concept Videos
Ziegler–Natta Chain-Growth Polymerization: Overview
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Reduction of Alkynes to cis-Alkenes: Catalytic Hydrogenation
Like alkenes, alkynes can be reduced to alkanes in the presence of transition metal catalysts such as Pt, Pd, or Ni. The reaction involves two sequential syn additions of hydrogen via a cis-alkene intermediate.
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Preparation of Alkynes: Alkylation Reaction
Alkylation of terminal alkynes with primary alkyl halides in the presence of a strong base like sodium amide is one of the common methods for the synthesis of longer carbon-chain alkynes. For example, treatment of 1-propyne with sodium amide followed by reaction with ethyl bromide yields 2-pentyne.