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A MoS2 based silver-doped ZnO nanocomposite and its antibacterial activity against β-lactamase expressing Escherichia

Atanu Naskar1, Joonho Shin1, Kwang-Sun Kim1

  • 1Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University Busan 46241 South Korea kwangsun.kim@pusan.ac.kr +82-51-516-7421 +82-51-510-2241.

RSC Advances
|April 15, 2022
PubMed

Insights

A novel molybdenum disulfide (MoS2)-based nanocomposite with silver-doped zinc oxide shows potent antibacterial activity against multidrug-resistant Escherichia coli. This nano-antibacterial platform offers selective targeting of specific bacterial resistance mechanisms.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Microbiology
  • Infectious Diseases

Background:

  • Multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli, pose a significant global health threat due to increasing antibiotic resistance.
  • Two-dimensional (2D) nanomaterials, particularly molybdenum disulfide (MoS2) nanosheets, exhibit promising physicochemical properties for developing novel antibacterial strategies.
  • MoS2's high surface area, conductivity, and surface retention make it suitable for bactericidal applications.

Purpose of the Study:

  • To fabricate and characterize a MoS2-based nanocomposite conjugated with silver-doped zinc oxide (AZM) as an effective antibacterial agent.
  • To evaluate the antibacterial activity of AZM against various multidrug-resistant E. coli strains with different resistance mechanisms.
  • To investigate the role of MoS2 in enhancing AZM's antibacterial efficacy and selectivity.

Main Methods:

  • Fabrication of a MoS2-AZM nanocomposite.
  • Characterization of the AZM nanocomposite properties.
  • Evaluation of antibacterial activity against MDR E. coli strains, including those expressing β-lactamases and the mobilized colistin resistance (mcr-1) gene.

Main Results:

  • The MoS2-AZM nanocomposite demonstrated effective antibacterial activity against MDR E. coli.
  • MoS2 enhanced AZM's antibacterial activity and provided selectivity against MDR E. coli strains expressing β-lactamases.
  • Bacterial cell wall membrane disruption was identified as the primary cell death mechanism; surface charge perturbation explained differential activity against strains with β-lactamase and mcr-1 resistance.

Conclusions:

  • A MoS2-based nanocomposite with a functional conjugation strategy presents a promising selective nano-antibacterial platform.
  • This platform is effective against infections caused by MDR E. coli, particularly those resistant to β-lactam antibiotics.
  • The findings highlight the potential of tailored nanomaterials for combating challenging bacterial infections.

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