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Updated: Sep 26, 2025

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
Medical Treatment of Overactive Bladder
Justin Loloi1, Whitney Clearwater2, Alison Schulz3
1Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, 1250 Waters Place, Tower 1 PH, Bronx, NY 10461, USA.
Abstract:
Overactive bladder is a disruptive urinary condition composed of urgency, frequency, and nocturia, which affects a large proportion of men and women. Symptoms are often associated with a decreased quality of life. After optimizing behavioral strategies, pharmacologic intervention is the next consideration for treatment. Therapeutic agents consist primarily of antimuscarinic and β-agonist medications, as well as off-label use of antidepressants in some cases. These medications, although effective, can be associated with considerable adverse side effects. Combination therapies along with novel therapeutics and drug targets are under investigation.
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