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Updated: Sep 26, 2025
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A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
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Are Histamine H3 Antagonists the Definitive Treatment for Acute Methamphetamine Intoxication?
Nobue Kitanaka1, F Scott Hall2, Koh-Ichi Tanaka3
1Department of Pharmacology, Hyogo College of Medicine, Hyogo 663-8501, Japan.
Current Drug Research Reviews
|April 18, 2022
Summary
Histamine H3 receptor antagonists show promise for treating methamphetamine (METH) use disorder. These compounds modulate brain histamine, potentially reversing some adverse effects of chronic METH abuse.
Area of Science:
- Neuroscience
- Pharmacology
- Addiction Research
Background:
- Methamphetamine (METH) is a highly addictive Schedule II stimulant with no established effective treatments for abuse or chronic use.
- Chronic METH use leads to largely irreversible brain function alterations and damage, necessitating novel therapeutic strategies.
- Histamine neurotransmission plays a role in neuropsychiatric disorders, including substance use disorders.
Conclusions:
- Histamine H3 receptors represent a potential therapeutic target for METH use disorder.
- Targeting H3 receptors may offer a novel approach to manage adverse effects associated with chronic METH use.
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