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COVID-19 and Vitamin D- a Systematic Review
Taja Jordan1, Darko Siuka2, Nada Kozjek Rotovnik3,4
1University Medical Centre Ljubljana, Department for Radiology, Zaloška c. 7, 1000 Ljubljana, Slovenia.
Zdravstveno Varstvo
|April 18, 2022
Summary
Vitamin D deficiency may increase the risk and severity of COVID-19. Supplementation is recommended to maintain adequate levels, potentially reducing critical illness and mortality in high-risk individuals.
Area of Science:
- Immunology
- Epidemiology
- Public Health
Background:
- COVID-19 pandemic significantly impacted global healthcare.
- Vitamin D influences innate immunity and cytokine storm pathogenesis.
- Previous studies link serum vitamin D to infectious disease incidence.
Purpose of the Study:
- To review the relationship between vitamin D levels and COVID-19 outcomes.
- To assess the role of vitamin D supplementation in managing COVID-19.
Main Methods:
- Systematic review of studies from PubMed and Google Scholar.
- Inclusion criteria applied to selected abstracts and full texts.
- Evaluation of 28 studies for observational findings.
Main Results:
- Observational data suggest a link between vitamin D levels and COVID-19 incidence, severity, and mortality.
- Vitamin D deficiency may elevate the risk and progression of COVID-19.
- No evidence suggests vitamin D can eliminate COVID-19.
Conclusions:
- Vitamin D supplementation is a viable strategy for deficiency correction.
- Recommended daily intake for adults is 1000-2000 IU.
- Supplementation may protect against severe acute respiratory infections and reduce COVID-19 mortality.
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