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pH Responsive Antibacterial Hydrogel Utilizing Catechol-Boronate Complexation Chemistry.

Bo Liu1, Jianghua Li2, Zhongtian Zhang1

  • 1Department of Biomedical Engineering, Michigan Technological University, Houghton, Michigan 49931, United States.

Chemical Engineering Journal (Lausanne, Switzerland : 1996)
|April 21, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a novel antibacterial hydrogel that effectively kills bacteria like MRSA in acidic conditions. The hydrogel regains its antimicrobial activity upon returning to acidic pH, offering a tunable approach to infection control.

Keywords:
antibacterialattenuated cytotoxicitycatechol–boronate complexationhalogenated catecholpH responsive

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Area of Science:

  • Biomaterials Science
  • Infectious Disease Research
  • Polymer Chemistry

Background:

  • Bacterial infections, including Methicillin-resistant Staphylococcus aureus (MRSA), create acidic microenvironments.
  • Developing pH-responsive biomaterials with tunable antimicrobial properties is crucial for effective infection management.

Purpose of the Study:

  • To present a novel antibacterial hydrogel with pH-dependent antimicrobial activity.
  • To investigate the reversible catechol-boronate linkage for controlled release of bactericidal agents.

Main Methods:

  • Fabrication of a hydrogel using chlorinated catechol (catechol-Cl) and phenylboronic acid.
  • Characterization of hydrogel properties using FTIR, oscillatory rheometry, and JKR contact mechanics.
  • Evaluation of antimicrobial efficacy against Gram-positive and Gram-negative bacteria at varying pH levels.

Main Results:

  • The hydrogel demonstrated pH-dependent formation and dissociation of catechol-boronate linkages.
  • At acidic pH (3), the hydrogel showed significant antimicrobial activity against MRSA (up to 4 log10 reduction).
  • At basic pH (8.5), the hydrogel became non-cytotoxic, with antimicrobial activity restored upon re-acidification.

Conclusions:

  • The novel hydrogel offers tunable antibacterial activity through pH-responsive catechol-boronate chemistry.
  • This approach provides a strategy for designing safer, effective antimicrobial hydrogels with reduced cytotoxicity.
  • The reversible nature of the linkage allows for controlled bacterial killing and potential for repeated use.