Functional Optical Coherence Tomography for Intrinsic Signal Optoretinography: Recent Developments and Deployment...

Area of Science:

• Ophthalmology
• Biomedical Imaging
• Retinal Physiology

Background:

• Intrinsic optical signal (IOS) imaging, also known as optoretinography (ORG), provides a non-invasive method for assessing retinal function.
• Functional optical coherence tomography (fOCT) enables differentiation of retinal layers for ORG measurements.

Purpose of the Study:

• To summarize recent advancements in functional OCT for ORG measurements.
• To discuss intensity- and phase-based IOS processing methods.
• To address challenges and future perspectives in quantitative IOS analysis and ORG interpretation.

Main Methods:

• Review of recent developments in functional OCT technology for ORG.
• Analysis of OCT intensity- and phase-based methods for IOS signal processing.
• Discussion of technical challenges in quantitative IOS analysis.

Main Results:

• Functional OCT shows promise for objective retinal function assessment.
• Standardized protocols and clearer understanding of IOS mechanisms are needed for clinical ORG deployment.
• Advances in IOS processing are crucial for quantitative ORG.

Conclusions:

• Functional OCT is a developing tool for non-invasive retinal function assessment via ORG.
• Overcoming challenges in standardization and IOS mechanism elucidation is critical for clinical translation.
• Further research into quantitative IOS analysis and ORG interpretation is warranted.