Related Experiment Video
Updated: Sep 26, 2025

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Irritant contact dermatitis caused by cosmetics containing excessive mercury
Sihao Sun1, Jinxiu Chang1, Xin Jiang1
1Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Background:
Irritant contact dermatitis (ICD) is a localized, nonimmune-induced inflammatory skin reaction, characterized by multiform skin lesions, including erythema, scaling, edema, blisters, and erosion. Mercury and its related compounds are highly allergic agents that can induce allergic contact dermatitis.
Aims:
This article aims to clarify the skin damage caused by irritant contact dermatitis caused by the addition of high doses of mercury to skin care products.
Patients:
A 30-year-old female patient sought treatment at our Institute for contact dermatitis.
Results:
Through the patch test of the patients and the component detection of the skin care products her use. A large amount of mercury was found in skin care products, and the patient had no apparent allergic reaction to mercury.
Conclusions:
We considered irritant contact dermatitis caused by excess mercury, and the patient's condition improved with treatment.
Related Concept Videos
Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
The Periodic Table and Organismal Elements
Periodic Table Provides Information...
Oxymercuration-Reduction of Alkenes
Vitamins

