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Updated: Sep 26, 2025

A Fast and Reliable Pipeline for Bacterial Transcriptome Analysis Case study: Serine-dependent Gene Regulation in Streptococcus pneumoniae
Published on: April 25, 2015
The growth-survival trade-off is hard-wired in the Lactococcus lactis gene regulation network
Onur Ercan1,2, Heidy M W den Besten3, Eddy J Smid1,3
1TiFN, Agro Business Park 82, Wageningen, 6708 PW, The Netherlands.
Abstract:
Most microbes reside in oligotrophic environments for extended periods of time, requiring survival strategies that maintain proliferative capacity. We demonstrate that the non-spore-forming Lactococcus lactis KF147 progressively activates the expression of stress-associated functions in response to the declining growth rate elicited by prolonged retentostat cultivation, which coincides with up to 104 -fold increased stress tolerance. Our findings provide a quantified view of the transcription and stress-tolerance adaptations underlying the growth-survival trade-off in L. lactis, and exemplify the hard-wiring of this trade-off in the lactococcal gene regulation network.
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