Related Experiment Video
Updated: Sep 26, 2025
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
518
Biomarkers in Oral Fluids as Diagnostic Tool for Psoriasis
Constanza Jiménez1, María José Bordagaray2, José Luis Villarroel3
1Faculty of Dentistry, Universidad Andres Bello, Santiago 8370133, Chile.
Life (Basel, Switzerland)
|April 23, 2022
Summary
Researchers explored biomarkers in saliva and gingival crevicular fluid (GCF) for diagnosing psoriasis. Distinct levels of inflammatory cytokines and other molecules were found in psoriasis patients, suggesting potential diagnostic tools.
Area of Science:
- Immunodermatology
- Oral Medicine
- Biomarker Discovery
Background:
- Psoriasis is a common chronic inflammatory skin condition affecting millions globally.
- Accurate diagnosis is crucial for timely treatment and improved patient quality of life.
- Oral fluids offer a non-invasive method for biomarker identification.
Purpose of the Study:
- To identify potential biomarkers in gingival crevicular fluid (GCF) and saliva for psoriasis diagnosis.
- To review existing literature on salivary and GCF biomarkers for psoriasis.
Main Methods:
- A narrative review of original research articles was conducted.
- Literature search utilized MESH terms: "psoriasis", "saliva", and "gingival crevicular fluid".
- Studies focused on original research available in English.
Main Results:
- Ten articles identified salivary biomarkers showing differences in inflammatory cytokines, immunoglobulin A, and antioxidants between healthy individuals and psoriasis patients.
- Three articles identified GCF biomarkers, with psoriasis patients exhibiting elevated S100A8, IL-18, and sE-selectin levels, irrespective of periodontal status.
Conclusions:
- Saliva and GCF contain potential biomarkers for psoriasis diagnosis.
- Further research is needed to establish a definitive panel of salivary or GCF biomarkers for clinical use in psoriasis detection.
