Related Experiment Video
Updated: Sep 26, 2025

Mouse Round Spermatid Injection
Published on: January 26, 2024
The Fate of Leydig Cells in Men with Spermatogenic Failure
Daria Adamczewska1, Jolanta Słowikowska-Hilczer1, Renata Walczak-Jędrzejowska1
1Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, 92-213 Lodz, Poland.
Abstract:
The steroidogenic cells in the testicle, Leydig cells, located in the interstitial compartment, play a vital role in male reproductive tract development, maintenance of proper spermatogenesis, and overall male reproductive function. Therefore, their dysfunction can lead to all sorts of testicular pathologies. Spermatogenesis failure, manifested as azoospermia, is often associated with defective Leydig cell activity. Spermatogenic failure is the most severe form of male infertility, caused by disorders of the testicular parenchyma or testicular hormone imbalance. This review covers current progress in knowledge on Leydig cells origin, structure, and function, and focuses on recent advances in understanding how Leydig cells contribute to the impairment of spermatogenesis.
More Related Videos
09:41Functional Assessment of Kinesin-7 CENP-E in Spermatocytes Using In Vivo Inhibition, Immunofluorescence and Flow Cytometry
Published on: December 28, 2021
09:40A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
Published on: February 6, 2018
Related Concept Videos
Spermatogenesis
Infertility in Males
Sperm Transport
The maturation phase occurs in the epididymis, where sperm...
Testes: Histology
The spermatogenic cells, responsible for producing sperm, are...
Testosterone: Functions and Regulation
Meiosis II