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Third-Line Antiretroviral Therapy: What Do We Do When the Appropriate Formulations Are Not Available?
Lisa Jane Frigati1, Helena Rabie1
1Department of Paediatrics, Child Health Stellenbosch University, Tygerberg Hospital, Cape Town 7505, South Africa.
Abstract:
Children on antiretroviral therapy have limited options, particularly if they are failing therapy and live in resource-poor settings. We describe three cases where children accessed third-line antiretroviral therapy off-label, or used them extemporaneously with successful outcomes. We then review the evidence for performing this measure. There is an urgent need for appropriate formulations to treat young children who require a third-line or salvage regimen.
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