Split-Face Comparative Analysis Of Micro-Needling With Tranexamic Acid Vs Vitamin C Serum In Melasma

Area of Science:

• Dermatology
• Aesthetic Medicine

Background:

• Melasma is a prevalent skin condition, particularly in women, causing significant psycho-social distress and reduced quality of life.
• Resistant melasma cases are emerging, necessitating novel treatment strategies beyond conventional first-line options.

Purpose of the Study:

• To investigate the efficacy of micro-needling combined with vitamin C and tranexamic acid for treating melasma.
• To compare the effectiveness of vitamin C versus tranexamic acid when administered via micro-needling.

Main Methods:

• A non-randomized clinical trial involving 30 patients (19 females, 11 males) with melasma.
• Patients received micro-needling with tranexamic acid on one side of the face and vitamin C on the other, with three bi-weekly sessions.
• Response was evaluated using Physician Global Assessment, Patient Global Assessment, and modified Melasma Area Severity Index at weeks 2, 4, and 6.

Main Results:

• Initial improvement was more pronounced with tranexamic acid after the first session.
• Both tranexamic acid and vitamin C demonstrated significant improvements in melasma severity and patient/physician global assessments by week 6.
• No statistically significant difference in efficacy was observed between tranexamic acid and vitamin C (p>0.05).

Conclusions:

• Micro-needling with either tranexamic acid or vitamin C serves as a potent adjuvant therapy for melasma.
• Both investigated treatments offer significant benefits for melasma patients, suggesting their utility in clinical practice.